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The Department of Neurosurgery Translational NeuroTrauma Laboratory (TNT) is the laboratory of Dr. Laura Ngwenya, MD, PhD. The TNT Laboratory focuses on the mechanisms that underlie poor recovery after traumatic brain injury (TBI). TBI affects more than 2.8 million people in the US annually. However, despite the widespread societal and economic impact, there are no effective treatments for traumatic brain injury. Especially devastating are the cognitive deficits that occur after TBI. The TNT Laboratory utilizes clinical research, bioinformatics, and an experimental model of TBI to explore the underlying mechanisms of poor recovery after TBI and search for potential treatments. We employ statistical and bioinformatics analyses, cognitive / behavioral testing, histology and immunohistochemistry, stereological quantification, electrophysiology, and molecular techniques. The current focus of our NIH funded laboratory is exploring the interplay between spreading depolarizations, adult neurogenesis, and TBI. We have many collaborators throughout UC and CCHMC, including Dr. Jennifer McGuire (Asst. Prof, Neurosurgery), Dr. Jed Hartings (Professor, Neurosurgery), Dr. Steve Danzer (Professor, Anesthesia, CCHMC), Dr. Brandon Foreman (Assoc. Prof, Neurology), and Dr. Danny Wu (Asst. Professor, Biomedical Informatics). The TNT laboratory is affiliated with the UCGNI Neurotrauma Center, as well as the Collaborative for Research on Acute Neurological Injuries (CRANI).
2025
Wongsripuemtet, Pattrapun; Ohnuma, Tetsu; Temkin, Nancy; Barber, Jason; Komisarow, Jordan; Manley, Geoffrey T; Hatfield, Jordan; Treggiari, Miriam M; Colton, Katharine; Sasannejad, Cina; Chaikittisilpa, Nophanan; Grandhi, Ramesh; Laskowitz, Daniel T; Mathew, Joseph P; Hernandez, Adrian; James, Michael L; Raghunathan, Karthik; Miller, Joseph B; Vavilala, Monica S; Krishnamoorthy, Vijay 2025. Association of Preinjury Beta-Blocker Exposure With Brain Injury Biomarkers Following Traumatic Brain Injury. Journal of neurosurgical anesthesiology, ,
DeSana, Anthony J; Alfawares, Yara; Khatri, Roshni; Hopkins, Tracy M; Best, Faith V; McGuire, Jennifer L; Ngwenya, Laura B 2025. Altered Neuroinflammatory Transcriptomic Profile in the Hippocampal Dentate Gyrus Three Weeks After Lateral Fluid Percussion Injury in Rats. International journal of molecular sciences, 26 18,
Schneider, Andrea L C; Hunzinger, Katherine J; Brett, Benjamin L; Sandsmark, Danielle K; Jain, Sonia; Sun, Xiaoying; Gardner, Raquel C; Manley, Geoffrey T; Diaz-Arrastia, Ramon; Nelson, Lindsay D ; Belton, Patrick; Eagle, Shawn; Gopinath, Shankar; Grandhi, Ramesh; Keene, C Dirk; Krishnamoorthy, Vijay; Mac Donald, Christine; McCrea, Michael; Merchant, Randall; Mukherjee, Pratik; Ngwenya, Laura B; Okonkwo, David; Robertson, Claudia; Schnyer, David; Taylor, Sabrina R; Yue, John K; Zafonte, Ross 2025. Vascular Risk Factors and 1-Year Cognitive Change Among Individuals With Traumatic Brain Injury. JAMA network open, 8 8, e2525719
Raksin, P B; Ngwenya, Laura B 2025. Neurocritical Care in Trauma. Neurosurgery clinics of North America, 36 3, xiii-xiv
Ivey, Natalie A; Ngwenya, Laura B; Shutter, Lori A 2025. Neuroprognostication and Ethical Considerations in Traumatic Brain Injury. Neurosurgery clinics of North America, 36 3, 451-457
Harris, Mark; Yue, John K; Jain, Sonia; Sun, Xiaoying; Puccio, Ava M; Gardner, Raquel C; Wang, Kevin K W; Okonkwo, David O; Yuh, Esther L; Mukherjee, Pratik; Nelson, Lindsay D; Taylor, Sabrina R; Markowitz, Amy J; Diaz-Arrastia, Ramon; Manley, Geoffrey T; Korley, Frederick K 2025. Effect of blood alcohol on the diagnostic accuracy of glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase L1 for traumatic intracranial hemorrhage: A TRACK-TBI study. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 32 7, 748-758
Lisi, Ilaria; Moro, Federico; Mazzone, Edoardo; Marklund, Niklas; Pischiutta, Francesca; Kobeissy, Firas; Mao, Xiang; Corrigan, Frances; Helmy, Adel; Nasrallah, Fatima; Pietro, Valentina Di; Ngwenya, Laura B; Portela, Luis V; Semple, Bridgette D; Schneider, Andrea L C; Arrastia, Ramon Diaz; Menon, David K; Smith, Douglas H; Wellington, Cheryl; Loane, David J; Wang, Kevin K W; Zanier, Elisa R 2025. Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury. Brain : a journal of neurology, 148 4, 1062-1080
Eagle, Shawn R; Barber, Jason; Temkin, Nancy; McCrea, Michael A; Giacino, Joseph T; Okonkwo, David O; Madhok, Debbie; Yue, John K; Zerbato, Jennifer M; Manley, Geoffrey T; Nelson, Lindsay D 2025. Follow up rates and patient interest in clinical care after mild traumatic brain injury presenting to a level 1 trauma center: a TRACK-TBI prospective cohort study. Frontiers in neurology, 16 , 1558204
Eagle, Shawn R; Gardner, Raquel C; Jain, Sonia; Sun, Xiaoying; Puccio, Ava; Brent, David; Nelson, Lindsay D; McCrea, Michael A; Giacino, Joseph T; Okonkwo, David O; Yue, John K; Manley, Geoffrey T; Stein, Murray B 2025. Association of blood-based glial fibrillary acidic protein level with depression and suicidal ideation following traumatic brain injury with Glasgow Coma Scale score 13 to 15: a TRACK-TBI study. Brain communications, 7 2, fcaf123
Best, Faith V; Hartings, Jed A; Ngwenya, Laura B 2025. Repetitive cortical spreading depolarizations are prolonged early after experimental traumatic brain injury. Experimental neurology, 385 , 115120
Best, Faith V; Hartings, Jed A; Alfawares, Yara; Danzer, Steve C; Ngwenya, Laura B 2025. Behavioral and Cognitive Consequences of Spreading Depolarizations: A Translational Scoping Review. Journal of neurotrauma, 42 1-2, 1-18
2024
Barrit, Sami; Al Barajraji, Mejdeddine; El Hadwe, Salim; Niset, Alexandre; Foreman, Brandon; Park, Soojin; Lazaridis, Christos; Shutter, Lori; Appavu, Brian; Kirschen, Matthew P; Montellano, Felipe A; Rass, Verena; Torcida, Nathan; Pinggera, Daniel; Gilmore, Emily; Ben-Hamouda, Nawfel; Massager, Nicolas; Bernard, Francis; Robba, Chiara; Taccone, Fabio Silvio 2024. Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus. Critical care (London, England), 28 1, 427
Kals, Mart; Wilson, Lindsay; Levey, Daniel F; Parodi, Livia; Steyerberg, Ewout W; Richardson, Sylvia; He, Feng; Sun, Xiaoying; Jain, Sonia; Palotie, Aarno; Ripatti, Samuli; Rosand, Jonathan; Manley, Geoff T; Maas, Andrew I R; Stein, Murray B; Menon, David K 2024. Genetic vulnerability and adverse mental health outcomes following mild traumatic brain injury: a meta-analysis of CENTER-TBI and TRACK-TBI cohorts. EClinicalMedicine, 78 , 102956
Foertsch, Madeline J; Beckett, Henry T; Dehne, Lauren M; Janusz, Stephanie; Ferioli, Simona; Ngwenya, Laura B; Droege, Molly E 2024. Management of severe traumatic brain injury in a rivaroxaban overdose: illustrative case. Journal of neurosurgery. Case lessons, 8 23,
Yue, John K; Kanter, John H; Barber, Jason K; Huang, Michael C; van Essen, Thomas A; Elguindy, Mahmoud M; Foreman, Brandon; Korley, Frederick K; Belton, Patrick J; Pisică, Dana; Lee, Young M; Kitagawa, Ryan S; Vassar, Mary J; Sun, Xiaoying; Satris, Gabriela G; Wong, Justin C; Ferguson, Adam R; Huie, J Russell; Wang, Kevin K W; Deng, Hansen; Wang, Vincent Y; Bodien, Yelena G; Taylor, Sabrina R; Madhok, Debbie Y; McCrea, Michael A; Ngwenya, Laura B; DiGiorgio, Anthony M; Tarapore, Phiroz E; Stein, Murray B; Puccio, Ava M; Giacino, Joseph T; Diaz-Arrastia, Ramon; Lingsma, Hester F; Mukherjee, Pratik; Yuh, Esther L; Robertson, Claudia S; Menon, David K; Maas, Andrew I R; Markowitz, Amy J; Jain, Sonia; Okonkwo, David O; Temkin, Nancy R; Manley, Geoffrey T 2024. Clinical profile of patients with acute traumatic brain injury undergoing cranial surgery in the United States: report from the 18-centre TRACK-TBI cohort study. Lancet regional health. Americas, 39 , 100915
Samanta, Romit J; Chiollaz, Anne-Cécile; Needham, Edward; Yue, John K; Helmy, Adel; Zanier, Elisa R; Wang, Kevin K W; Kobeissy, Firas; Posti, Jussi P; Summers, Charlotte; Manley, Geoffrey T; Maas, Andrew Ir; Tenovuo, Olli; Sanchez, Jean-Charles; Menon, David K 2024. Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury. EBioMedicine, 108 , 105310
Luna, Rudy; Basil, Barbara; Ewbank, Davis; Kasturiarachi, Brittany M; Mizrahi, Moshe A; Ngwenya, Laura B; Foreman, Brandon 2024. Clinical Impact of Standardized Interpretation and Reporting of Multimodality Neuromonitoring Data. Critical care explorations, 6 8, e1139
Yue, John K; Lee, Young M; Sun, Xiaoying; van Essen, Thomas A; Elguindy, Mahmoud M; Belton, Patrick J; Pisică, Dana; Mikolic, Ana; Deng, Hansen; Kanter, John H; McCrea, Michael A; Bodien, Yelena G; Satris, Gabriela G; Wong, Justin C; Ambati, Vardhaan S; Grandhi, Ramesh; Puccio, Ava M; Mukherjee, Pratik; Valadka, Alex B; Tarapore, Phiroz E; Huang, Michael C; DiGiorgio, Anthony M; Markowitz, Amy J; Yuh, Esther L; Okonkwo, David O; Steyerberg, Ewout W; Lingsma, Hester F; Menon, David K; Maas, Andrew I R; Jain, Sonia; Manley, Geoffrey T 2024. Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study. Journal of neurosurgery, 141 2, 417-429
Yue, John K; Etemad, Leila L; Elguindy, Mahmoud M; van Essen, Thomas A; Belton, Patrick J; Nelson, Lindsay D; McCrea, Michael A; Vreeburg, Rick J G; Gotthardt, Christine J; Tracey, Joye X; Coskun, Bukre C; Krishnan, Nishanth; Halabi, Cathra; Eagle, Shawn R; Korley, Frederick K; Robertson, Claudia S; Duhaime, Ann-Christine; Satris, Gabriela G; Tarapore, Phiroz E; Huang, Michael C; Madhok, Debbie Y; Giacino, Joseph T; Mukherjee, Pratik; Yuh, Esther L; Valadka, Alex B; Puccio, Ava M; Okonkwo, David O; Sun, Xiaoying; Jain, Sonia; Manley, Geoffrey T; DiGiorgio, Anthony M ; Badjatia, Neeraj; Barber, Jason; Bodien, Yelena G; Fabian, Brian; Ferguson, Adam R; Foreman, Brandon; Gardner, Raquel C; Gopinath, Shankar; Grandhi, Ramesh; Russell Huie, J; Dirk Keene, C; Lingsma, Hester F; MacDonald, Christine L; Markowitz, Amy J; Merchant, Randall; Ngwenya, Laura B; Rodgers, Richard B; Schneider, Andrea L C; Schnyer, David M; Taylor, Sabrina R; Temkin, Nancy R; Torres-Espin, Abel; Vassar, Mary J; Wang, Kevin K W; Wong, Justin C; Zafonte, Ross D 2024. Prior traumatic brain injury is a risk factor for in-hospital mortality in moderate to severe traumatic brain injury: a TRACK-TBI cohort study. Trauma surgery & acute care open, 9 1, e001501
Knott, Maxon V; Bacevich, Blake M; West, Rebekah; Wosiski-Kuhn, Marlena; McGrath, Kyle; Divine, Jon G; Ngwenya, Laura B 2024. Elucidating differences in concussion subtype symptomatology in sports-related versus non-sports-related concussions: a retrospective cohort study. Neurosurgical focus, 57 1, E7
Harlan, Sarah Schuman; Philpott, Carolyn D; Keegan, Shaun P; Droege, Molly E; Karve, Aniruddha S; Foreman, Brandon; Wakefield, Devin; Mueller, Eric W; Sangha, Kiranpal; Ngwenya, Laura B; Courter, Joshua D; Desai, Pankaj; Droege, Christopher 2024. Pharmacokinetics of Levetiracetam Seizure Prophylaxis in Severe Traumatic Brain Injury. The Annals of pharmacotherapy, 58 7, 705-714
Johnson, Mark D; Ventre, Giancarlo J; Kaye, Joel; Patel, Hemchandra B; Naveed, Asad; Prestigiacomo, Charles J; Ngwenya, Laura B 2024. Evaluating mortality and 6-month functional outcomes of patients with dural venous sinus thrombosis in traumatic brain injury. Journal of neurosurgery, 140 6, 1690-1699
Wu, Tzu-Chun; Kim, Abraham; Tsai, Ching-Tzu; Gao, Andy; Ghuman, Taran; Paul, Anne; Castillo, Alexandra; Cheng, Joseph; Adogwa, Owoicho; Ngwenya, Laura B; Foreman, Brandon; Wu, Danny T Y 2024. A Neurosurgical Readmissions Reduction Program in an Academic Hospital Leveraging Machine Learning, Workflow Analysis, and Simulation. Applied clinical informatics, 15 3, 479-488
Werner, J Kent; Albrecht, Jennifer; Capaldi, Vincent F; Jain, Sonia; Sun, Xiaoying; Mukherjee, Pratik; Williams, Scott G; Collen, Jacob; Diaz-Arrastia, Ramon; Manley, Geoffrey T; Krystal, Andrew D; Wickwire, Emerson 2024. Association of Biomarkers of Neuronal Injury and Inflammation With Insomnia Trajectories After Traumatic Brain Injury: A TRACK-TBI Study. Neurology, 102 8, e209269
Cai, Lanya T; Moon, Joseph; Camacho, Paul B; Anderson, Aaron T; Chwa, Won Jong; Sutton, Bradley P; Markowitz, Amy J; Palacios, Eva M; Rodriguez, Alexis; Manley, Geoffrey T; Shankar, Shivsundaram; Bremer, Peer-Timo; Mukherjee, Pratik; Madduri, Ravi K 2024. MaPPeRTrac: A Massively Parallel, Portable, and Reproducible Tractography Pipeline. Neuroinformatics, 22 2, 177-191
Liu, Sunny Yang; Kelly-Hedrick, Margot; Temkin, Nancy; Barber, Jason; Komisarow, Jordan; Hatfield, Jordan; Ohnuma, Tetsu; Manley, Geoffrey; Treggiari, Miriam M; Colton, Katharine; Vavilala, Monica S; Grandhi, Ramesh; Laskowitz, Daniel T; Mathew, Joseph P; Hernandez, Adrian; James, Michael L; Raghunathan, Karthik; Goldstein, Ben; Markowitz, Amy; Krishnamoorthy, Vijay 2024. Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study. Critical care medicine, 52 4, 607-617
Roberts, Christopher J; Barber, Jason; Temkin, Nancy R; Dong, Athena; Robertson, Claudia S; Valadka, Alex B; Yue, John K; Markowitz, Amy J; Manley, Geoffrey T; Nelson, Lindsay D ; Badjatia, Neeraj; Diaz-Arrastia, Ramon; Duhaime, Ann-Christine; Feeser, V Ramana; Gopinath, Shankar; Grandhi, Ramesh; Jha, Ruchira; Keene, C Dirk; Madden, Christopher; McCrea, Michael; Merchant, Randall; Ngwenya, Laura B; Rodgers, Richard B; Schnyer, David; Taylor, Sabrina R; Zafonte, Ross 2024. Clinical Outcomes After Traumatic Brain Injury and Exposure to Extracranial Surgery: A TRACK-TBI Study. JAMA surgery, 159 3, 248-259
Cai, Lanya T; Brett, Benjamin L; Palacios, Eva M; Yuh, Esther L; Bourla, Ioanna; Wren-Jarvis, Jamie; Wang, Yang; Mac Donald, Christine; Diaz-Arrastia, Ramon; Giacino, Joseph T; Okonkwo, David O; Levin, Harvey S; Robertson, Claudia S; Temkin, Nancy; Markowitz, Amy J; Manley, Geoffrey T; Stein, Murray B; McCrea, Michael A; Zafonte, Ross D; Nelson, Lindsay D; Mukherjee, Pratik 2024. Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury. Biological psychiatry. Cognitive neuroscience and neuroimaging, 9 2, 164-175
2023
Bryant, Andrew M; Rose, Nathan B; Temkin, Nancy R; Barber, Jason K; Manley, Geoffrey T; McCrea, Michael A; Nelson, Lindsay D ; Badjatia, Neeraj; Gopinath, Shankar; Keene, C Dirk; Madden, Christopher; Ngwenya, Laura B; Puccio, Ava; Robertson, Claudia; Schnyer, David; Taylor, Sabrina R; Yue, John K 2023. Profiles of Cognitive Functioning at 6 Months After Traumatic Brain Injury Among Patients in Level I Trauma Centers: A TRACK-TBI Study. JAMA network open, 6 12, e2349118
Tritt, Andrew; Yue, John K; Ferguson, Adam R; Torres Espin, Abel; Nelson, Lindsay D; Yuh, Esther L; Markowitz, Amy J; Manley, Geoffrey T; Bouchard, Kristofer E 2023. Data-driven distillation and precision prognosis in traumatic brain injury with interpretable machine learning. Scientific reports, 13 1, 21200
Foreman, Brandon; Kapinos, Gregory; Wainwright, Mark S; Ngwenya, Laura B; O'Phelan, Kristine H; LaRovere, Kerri L; Kirschen, Matthew P; Appavu, Brian; Lazaridis, Christos; Alkhachroum, Ayham; Maciel, Carolina B; Amorim, Edilberto; Chang, Jason J; Gilmore, Emily J; Rosenthal, Eric S; Park, Soojin 2023. Practice Standards for the Use of Multimodality Neuromonitoring: A Delphi Consensus Process. Critical care medicine, 51 12, 1740-1753
Snider, Samuel B; Temkin, Nancy R; Barber, Jason; Edlow, Brian L; Giacino, Joseph T; Hammond, Flora M; Izzy, Saef; Kowalski, Robert G; Markowitz, Amy J; Rovito, Craig A; Shih, Shirley L; Zafonte, Ross D; Manley, Geoffrey T; Bodien, Yelena G 2023. Predicting Functional Dependency in Patients with Disorders of Consciousness: A TBI-Model Systems and TRACK-TBI Study. Annals of neurology, 94 6, 1008-1023
Ashina, Håkan; Dodick, David W; Barber, Jason; Temkin, Nancy R; Chong, Catherine D; Adler, Jennifer S; Stein, Ken Shubin; Schwedt, Todd J; Manley, Geoffrey T 2023. Prevalence of and Risk Factors for Post-traumatic Headache in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study. Mayo Clinic proceedings, 98 10, 1515-1526
Hartings, Jed A; Dreier, Jens P; Ngwenya, Laura B; Balu, Ramani; Carlson, Andrew P; Foreman, Brandon 2023. Improving Neurotrauma by Depolarization Inhibition With Combination Therapy: A Phase 2 Randomized Feasibility Trial. Neurosurgery, 93 4, 924-931
Yamani, Ali S; Johnson, Mark D; Smith, Matthew S; Ngwenya, Laura B; Prestigiacomo, Charles J 2023. Post-traumatic Middle Meningeal Artery Pseudoaneurysm Treated With Endovascular Coil Embolization. Cureus, 15 9, e45402
Etemad, Leila L; Yue, John K; Barber, Jason; Nelson, Lindsay D; Bodien, Yelena G; Satris, Gabriela G; Belton, Patrick J; Madhok, Debbie Y; Huie, J Russell; Hamidi, Sabah; Tracey, Joye X; Coskun, Bukre C; Wong, Justin C; Yuh, Esther L; Mukherjee, Pratik; Markowitz, Amy J; Huang, Michael C; Tarapore, Phiroz E; Robertson, Claudia S; Diaz-Arrastia, Ramon; Stein, Murray B; Ferguson, Adam R; Puccio, Ava M; Okonkwo, David O; Giacino, Joseph T; McCrea, Michael A; Manley, Geoffrey T; Temkin, Nancy R; DiGiorgio, Anthony M 2023. Longitudinal Recovery Following Repetitive Traumatic Brain Injury. JAMA network open, 6 9, e2335804
Brett, Benjamin L; Temkin, Nancy; Barber, Jason K; Okonkwo, David O; Stein, Murray; Bodien, Yelena G; Corrigan, John; Diaz-Arrastia, Ramon; Giacino, Joseph T; McCrea, Michael A; Manley, Geoffrey T; Nelson, Lindsay D 2023. Long-term Multidomain Patterns of Change After Traumatic Brain Injury: A TRACK-TBI LONG Study. Neurology, 101 7, e740-e753
Xu, Alice; Venugopal, Vysakh; Aryal, Manish Raj; Alfawares, Yara; Matur, Abhijith V; Cheng, Joshua; Kosco, Ethan; McConaha, Matthew; Ghalsasi, Omkar; Lockett, Demiah; Bal, Gabriella; Andaluz, Norberto; Ngwenya, Laura B; Anand, Sam; Forbes, Jonathan 2023. Toward global availability of low-cost, patient-specific cranial implants: creation and validation of automated CranialRebuild freeware application. Acta neurochirurgica, 165 8, 2219-2224
Sibilia, Francesca; Custer, Rachel M; Irimia, Andrei; Sepehrband, Farshid; Toga, Arthur W; Cabeen, Ryan P 2023. Life After Mild Traumatic Brain Injury: Widespread Structural Brain Changes Associated With Psychological Distress Revealed With Multimodal Magnetic Resonance Imaging. Biological psychiatry global open science, 3 3, 374-385
Yue, John K; Krishnan, Nishanth; Kanter, John H; Deng, Hansen; Okonkwo, David O; Puccio, Ava M; Madhok, Debbie Y; Belton, Patrick J; Lindquist, Britta E; Satris, Gabriela G; Lee, Young M; Umbach, Gray; Duhaime, Ann-Christine; Mukherjee, Pratik; Yuh, Esther L; Valadka, Alex B; DiGiorgio, Anthony M; Tarapore, Phiroz E; Huang, Michael C; Manley, Geoffrey T 2023. Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study. Journal of clinical medicine, 12 5,
Gardner, Raquel C; Puccio, Ava M; Korley, Frederick K; Wang, Kevin K W; Diaz-Arrastia, Ramon; Okonkwo, David O; Puffer, Ross C; Yuh, Esther L; Yue, John K; Sun, Xiaoying; Taylor, Sabrina R; Mukherjee, Pratik; Jain, Sonia; Manley, Geoffrey T 2023. Effects of age and time since injury on traumatic brain injury blood biomarkers: a TRACK-TBI study. Brain communications, 5 1, fcac316
2022
Foreman, Brandon; Lee, Hyunjo; Okonkwo, David O; Strong, Anthony J; Pahl, Clemens; Shutter, Lori A; Dreier, Jens P; Ngwenya, Laura B; Hartings, Jed A 2022. The Relationship Between Seizures and Spreading Depolarizations in Patients with Severe Traumatic Brain Injury. Neurocritical care, ,
Ikeda, Daniel S; Chiocca, E Antonio; Lonser, Russel R; Sutton, Tracy E; McGregor, John M; Rea, Gary L; Schunemann, Victoria A; Ngwenya, Laura B; Marlin, Evan S; Porensky, Paul N; Shaikhouni, Ammar; Huntoon, Kristin; Dornbos, David; Shaw, Andrew B; Thoman, William J; Powers, Ciarán J 2022. Carole A. Miller, MD: Matriarch of the Ohio State University's Department of Neurosurgery. World neurosurgery, 166 , 33-38
Bodien, Yelena G; Barber, Jason; Taylor, Sabrina R; Boase, Kim Dawn; Corrigan, John D; Dikmen, Sureyya; Gardner, Raquel C; Kramer, Joel; Levin, Harvey; Machamer, Joan; McAllister, Thomas; Nelson, Lindsay D; Ngwenya, Laura Benjamin; Sherer, Mark; Stein, Murray B; Vassar, Mary J; Whyte, John; Yue, John K; Markowitz, Amy J; McCrea, Michael; Manley, Geoffrey T; Temkin, Nancy; Giacino, Joseph 2022. Feasibility and utility of a flexible outcome assessment battery for longitudinal traumatic brain injury research: A TRACK-TBI study. Journal of neurotrauma, ,
Alfawares, Yara; Folz, Caroline; Johnson, Mark D; Prestigiacomo, Charles J; Ngwenya, Laura B 2022. The history of antibiotic irrigation and prophylaxis in operative neurotrauma: perpetuation of military care in civilian settings. Neurosurgical focus, 53 3, E7
Bradshaw, Paige Garber; Keegan, Shaun; Foertsch, Madeline; Yang, George L; Ngwenya, Laura B; Srinivasan, Vasisht 2022. Andexanet alfa after 4-factor PCC administration for intracranial hemorrhage: a case series. Journal of thrombosis and thrombolysis, 54 2, 295-300
Yang, George L; Johnson, Mark D; Solomon, Daniel; Ferguson, Andrew M; Johnson, Reid A; Gerges, Christina; Wright, James M; Parr, Ann M; Ngwenya, Laura B 2022. The Effects of the COVID-19 Pandemic on Penetrating Neurotrauma at a Level 1 Trauma Center. World neurosurgery, 164 , e530-e539
Johnson, Reid A; Eaton, Anne; Tignanelli, Christopher J; Carrabre, Kailey J; Gerges, Christina; Yang, George L; Hemmila, Mark R; Ngwenya, Laura B; Wright, James M; Parr, Ann M 2022. Changes in patterns of traumatic brain injury in the Michigan Trauma Quality Improvement Program database early in the COVID-19 pandemic. Journal of neurosurgery, , 1-11
Johnson, Mark D; Stolz, Uwe; Carroll, Christopher P; Yang, George L; Andaluz, Norberto; Foreman, Brandon; Kreitzer, Natalie; Goodman, Michael D; Ngwenya, Laura B 2022. An independent, external validation and component analysis of the Surviving Penetrating Injury to the Brain score for civilian cranial gunshot injuries. Journal of neurosurgery, , 1-8
Machamer, Joan; Temkin, Nancy; Dikmen, Sureyya; Nelson, Lindsay D; Barber, Jason; Hwang, Phillip; Boase, Kim; Stein, Murray B; Sun, Xiaoying; Giacino, Joseph; McCrea, Michael A; Taylor, Sabrina R; Jain, Sonia; Manley, Geoff 2022. Symptom Frequency and Persistence in the First Year after Traumatic Brain Injury: A TRACK-TBI Study. Journal of neurotrauma, 39 5-6, 358-370
Galimberti, Stefania; Graziano, Francesca; Maas, Andrew I R; Isernia, Giulia; Lecky, Fiona; Jain, Sonia; Sun, Xiaoying; Gardner, Raquel C; Taylor, Sabrina R; Markowitz, Amy J; Manley, Geoffrey T; Valsecchi, Maria Grazia; Bellelli, Giuseppe; Citerio, Giuseppe 2022. Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation. The Lancet. Neurology, 21 2, 153-162
2021
Wright, James M; Gerges, Christina; Shammassian, Berje; Labak, Collin M; Herring, Eric Z; Miller, Benjamin; Alkhachroum, Ayham; Kottapally, Mohan; Huang Wright, Christina; Rodgers, Richard B; Sedney, Cara; Ngwenya, Laura B; Stippler, Martina; Sieg, Emily; Babu, Maya A; Hoffer, Alan; Hejal, Rana 2021. Prone Position Ventilation in Neurologically Ill Patients: A Systematic Review and Proposed Protocol. Critical care medicine, ,
Robinson, Michael W; Prestigiacomo, Charles J; Ngwenya, Laura B 2021. Commentary: Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials. Neurosurgery, 88 5, E394-E395
Robinson, David; Pyle, Logan; Foreman, Brandon; Ngwenya, Laura B; Adeoye, Opeolu; Woo, Daniel; Kreitzer, Natalie 2021. Antithrombotic regimens and need for critical care interventions among patients with subdural hematomas. The American journal of emergency medicine, 47 , 6-12
Casillo, Stephanie M; Venkatesh, Anisha; Muthiah, Nallammai; Agarwal, Nitin; Scott, Teresa; Romani, Rossana; Fernández, Laura L; Aristizabal, Sarita; Ginalis, Elizabeth E; Ozair, Ahmad; Bhat, Vivek; Faruqi, Arjumand; Bajaj, Ankur; Sonkar, Abhinav Arun; Ikeda, Daniel S; Chiocca, E Antonio; Lonser, Russell R; Sutton, Tracy E; McGregor, John M; Rea, Gary L; Schunemann, Victoria A; Ngwenya, Laura B; Marlin, Evan S; Porensky, Paul N; Shaikhouni, Ammar; Huntoon, Kristin; Dornbos, David; Shaw, Andrew B; Powers, Ciarán J; Gluski, Jacob M; Culver, Lauren G; Goodwin, Alyssa M; Ham, Steven; Marupudi, Neena I; Bhat, Dhananjaya I; Berry, Katherine M; Wu, Eva M; Wang, Michael Y 2021. Biographies of international women leaders in neurosurgery. Neurosurgical focus, 50 3, E19
Correll, Erika A; Ramser, Benjamin J; Knott, Maxon V; McCullumsmith, Robert E; McGuire, Jennifer L; Ngwenya, Laura B 2021. Deficits in pattern separation and dentate gyrus proliferation after rodent lateral fluid percussion injury. IBRO neuroscience reports, 10 , 31-41
Knott, Maxon V; Ngwenya, Laura B; Correll, Erika A; Bohnert, Judy; Ziemba, Noah J; Allgire, Emily; Hopkins, Tracy; McGuire, Jennifer L 2021. Lack of Glutamate Receptor Subunit Expression Changes in Hippocampal Dentate Gyrus after Experimental Traumatic Brain Injury in a Rodent Model of Depression. International journal of molecular sciences, 22 15,
Robinson, David; Kreitzer, Natalie; Ngwenya, Laura B; Adeoye, Opeolu; Woo, Daniel; Hartings, Jed; Foreman, Brandon 2021. Diffusion-Weighted Imaging Reveals Distinct Patterns of Cytotoxic Edema in Patients with Subdural Hematomas. Journal of neurotrauma, ,
Foreman, Brandon; Lee, Hyunjo; Mizrahi, Moshe A; Hartings, Jed A; Ngwenya, Laura B; Privitera, Michael; Tortella, Frank C; Zhang, Nanhua; Kramer, Joel H 2021. Seizures and Cognitive Outcome After Traumatic Brain Injury: A Post Hoc Analysis. Neurocritical care, ,
Wright, James; Elder, Theresa; Gerges, Christina; Reisen, Breanne; Wright, Christina; Jella, Tarun; Shah, Sanjit; Yang, George; Ngwenya, Laura B; Wang, Vincent; Parr, Ann M 2021. A systematic review of telehealth for the delivery of emergent neurosurgical care. Journal of telemedicine and telecare, 27 5, 261-268
Bodien, Yelena G; Barra, Alice; Temkin, Nancy R; Barber, Jason; Foreman, Brandon; Vassar, Mary; Robertson, Claudia; Taylor, Sabrina R; Markowitz, Amy J; Manley, Geoffrey T; Giacino, Joseph T; Edlow, Brian L 2021. Diagnosing Level of Consciousness: The Limits of the Glasgow Coma Scale Total Score. Journal of neurotrauma, 38 23, 3295-3305
Kreitzer, Natalie; Jain, Sonia; Young, Jacob S; Sun, Xiaoying; Stein, Murray B; McCrea, Michael A; Levin, Harvey S; Giacino, Joseph T; Markowitz, Amy J; Manley, Geoffrey T; Nelson, Lindsay D 2021. Comparing the Quality of Life after Brain Injury-Overall Scale and Satisfaction with Life Scale as Outcome Measures for Traumatic Brain Injury Research. Journal of neurotrauma, 38 23, 3352-3363
Rincon, Sandra P; Mukherjee, Pratik; Levin, Harvey S; Temkin, Nancy R; Mac Donald, Christine L; Krainak, Daniel M; Sun, Xiaoying; Jain, Sonia; Taylor, Sabrina R; Markowitz, Amy J; Kumar, Allison; Manley, Geoffrey T; Yuh, Esther L 2021. Interrater Reliability of National Institutes of Health Traumatic Brain Injury Imaging Common Data Elements for Brain Magnetic Resonance Imaging in Mild Traumatic Brain Injury. Journal of neurotrauma, 38 20, 2831-2840
Williams, John R; Nieblas-Bedolla, Edwin; Feroze, Abdullah; Young, Christopher; Temkin, Nancy R; Giacino, Joseph T; Okonkwo, David O; Manley, Geoffrey T; Barber, Jason; Durfy, Sharon; Markowitz, Amy J; Yuh, Esther L; Mukherjee, Pratik; Mac Donald, Christine L 2021. Prognostic Value of Hemorrhagic Brainstem Injury on Early Computed Tomography: A TRACK-TBI Study. Neurocritical care, 35 2, 335-346
Huie, J Russell; Mondello, Stefania; Lindsell, Christopher J; Antiga, Luca; Yuh, Esther L; Zanier, Elisa R; Masson, Serge; Rosario, Bedda L; Ferguson, Adam R 2021. Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations. Journal of neurotrauma, 38 18, 2514-2529
Nielson, Jessica L; Cooper, Shelly R; Seabury, Seth A; Luciani, Davide; Fabio, Anthony; Temkin, Nancy R; Ferguson, Adam R 2021. Statistical Guidelines for Handling Missing Data in Traumatic Brain Injury Clinical Research. Journal of neurotrauma, 38 18, 2530-2537
Yuh, Esther L; Jain, Sonia; Sun, Xiaoying; Pisica, Dana; Harris, Mark H; Taylor, Sabrina R; Markowitz, Amy J; Mukherjee, Pratik; Verheyden, Jan; Giacino, Joseph T; Levin, Harvey S; McCrea, Michael; Stein, Murray B; Temkin, Nancy R; Diaz-Arrastia, Ramon; Robertson, Claudia S; Lingsma, Hester F; Okonkwo, David O; Maas, Andrew I R; Manley, Geoffrey T ; Adeoye, Opeolu; Badjatia, Neeraj; Boase, Kim; Bodien, Yelena; Corrigan, John D; Crawford, Karen; Dikmen, Sureyya; Duhaime, Ann-Christine; Ellenbogen, Richard; Feeser, V Ramana; Ferguson, Adam R; Foreman, Brandon; Gardner, Raquel; Gaudette, Etienne; Gonzalez, Luis; Gopinath, Shankar; Gullapalli, Rao; Hemphill, J Claude; Hotz, Gillian; Keene, C Dirk; Kramer, Joel; Kreitzer, Natalie; Lindsell, Chris; Machamer, Joan; Madden, Christopher; Martin, Alastair; McAllister, Thomas; Merchant, Randall; Nelson, Lindsay; Ngwenya, Laura B; Noel, Florence; Nolan, Amber; Palacios, Eva; Perl, Daniel; Rabinowitz, Miri; Rosand, Jonathan; Sander, Angelle; Satris, Gabriella; Schnyer, David; Seabury, Seth; Toga, Arthur; Valadka, Alex; Vassar, Mary; Zafonte, Ross 2021. Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. JAMA neurology, 78 9, 1137-1148
Boase, Kim; Machamer, Joan; Temkin, Nancy R; Dikmen, Sureyya; Wilson, Lindsay; Nelson, Lindsay D; Barber, Jason; Bodien, Yelena G; Giacino, Joseph T; Markowitz, Amy J; McCrea, Michael A; Satris, Gabriela; Stein, Murray B; Taylor, Sabrina R; Manley, Geoffrey T 2021. Central Curation of Glasgow Outcome Scale-Extended Data: Lessons Learned from TRACK-TBI. Journal of neurotrauma, 38 17, 2419-2434
Agtarap, Stephanie; Kramer, Mark D; Campbell-Sills, Laura; Yuh, Esther; Mukherjee, Pratik; Manley, Geoffrey T; McCrea, Michael A; Dikmen, Sureyya; Giacino, Joseph T; Stein, Murray B; Nelson, Lindsay D 2021. Invariance of the Bifactor Structure of Mild Traumatic Brain Injury (mTBI) Symptoms on the Rivermead Postconcussion Symptoms Questionnaire Across Time, Demographic Characteristics, and Clinical Groups: A TRACK-TBI Study. Assessment, 28 6, 1656-1670
McCrea, Michael A; Giacino, Joseph T; Barber, Jason; Temkin, Nancy R; Nelson, Lindsay D; Levin, Harvey S; Dikmen, Sureyya; Stein, Murray; Bodien, Yelena G; Boase, Kim; Taylor, Sabrina R; Vassar, Mary; Mukherjee, Pratik; Robertson, Claudia; Diaz-Arrastia, Ramon; Okonkwo, David O; Markowitz, Amy J; Manley, Geoffrey T ; Adeoye, Opeolu; Badjatia, Neeraj; Bullock, M Ross; Chesnut, Randall; Corrigan, John D; Crawford, Karen; Duhaime, Ann-Christine; Ellenbogen, Richard; Feeser, V Ramana; Ferguson, Adam R; Foreman, Brandon; Gardner, Raquel; Gaudette, Etienne; Goldman, Dana; Gonzalez, Luis; Gopinath, Shankar; Gullapalli, Rao; Hemphill, J Claude; Hotz, Gillian; Jain, Sonia; Keene, C Dirk; Korley, Frederick K; Kramer, Joel; Kreitzer, Natalie; Lindsell, Chris; Machamer, Joan; Madden, Christopher; Martin, Alastair; McAllister, Thomas; Merchant, Randall; Ngwenya, Laura B; Noel, Florence; Nolan, Amber; Palacios, Eva; Perl, Daniel; Puccio, Ava; Rabinowitz, Miri; Rosand, Jonathan; Sander, Angelle; Satris, Gabriella; Schnyer, David; Seabury, Seth; Sherer, Mark; Toga, Arthur; Valadka, Alex; Wang, Kevin; Yue, John K; Yuh, Esther; Zafonte, Ross 2021. Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study. JAMA neurology, 78 8, 982-992
Nolan, Amber L; Petersen, Cathrine; Iacono, Diego; Mac Donald, Christine L; Mukherjee, Pratik; van der Kouwe, Andre; Jain, Sonia; Stevens, Allison; Diamond, Bram R; Wang, Ruopeng; Markowitz, Amy J; Fischl, Bruce; Perl, Daniel P; Manley, Geoffrey T; Keene, C Dirk; Diaz-Arrastia, Ramon; Edlow, Brian L 2021. Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study. Journal of neurotrauma, 38 12, 1620-1631
Levin, Harvey S; Temkin, Nancy R; Barber, Jason; Nelson, Lindsay D; Robertson, Claudia; Brennan, Jeffrey; Stein, Murray B; Yue, John K; Giacino, Joseph T; McCrea, Michael A; Diaz-Arrastia, Ramon; Mukherjee, Pratik; Okonkwo, David O; Boase, Kim; Markowitz, Amy J; Bodien, Yelena; Taylor, Sabrina; Vassar, Mary J; Manley, Geoffrey T ; Adeoye, Opeolu; Badjatia, Neeraj; Bullock, M Ross; Chesnut, Randall; Corrigan, John D; Crawford, Karen; Dikmen, Sureyya; Duhaime, Ann-Christine; Ellenbogen, Richard; Feeser, V Ramana; Ferguson, Adam R; Foreman, Brandon; Gardner, Raquel; Gaudette, Etienne; Gonzalez, Luis; Gopinath, Shankar; Gullapalli, Rao; Hemphill, J Claude; Hotz, Gillian; Jain, Sonia; Keene, C Dirk; Korley, Frederick K; Kramer, Joel; Kreitzer, Natalie; Lindsell, Chris; Machamer, Joan; Madden, Christopher; Martin, Alastair; McAllister, Thomas; Merchant, Randall; Nolan, Amber; Ngwenya, Laura B; Noel, Florence; Palacios, Eva; Puccio, Ava; Rabinowitz, Miri; Rosand, Jonathan; Sander, Angelle; Satris, Gabriella; Schnyer, David; Seabury, Seth; Sun, Xiaoying; Toga, Arthur; Valadka, Alex; Wang, Kevin; Yuh, Esther; Zafonte, Ross 2021. Association of Sex and Age With Mild Traumatic Brain Injury-Related Symptoms: A TRACK-TBI Study. JAMA network open, 4 4, e213046
Xu, Linda B; Yue, John K; Korley, Frederick; Puccio, Ava M; Yuh, Esther L; Sun, Xiaoying; Rabinowitz, Miri; Vassar, Mary J; Taylor, Sabrina R; Winkler, Ethan A; Puffer, Ross C; Deng, Hansen; McCrea, Michael; Stein, Murray B; Robertson, Claudia S; Levin, Harvey S; Dikmen, Sureyya; Temkin, Nancy R; Giacino, Joseph T; Mukherjee, Pratik; Wang, Kevin K W; Okonkwo, David O; Markowitz, Amy J; Jain, Sonia; Manley, Geoffrey T; Diaz-Arrastia, Ramon 2021. High-Sensitivity C-Reactive Protein is a Prognostic Biomarker of Six-Month Disability after Traumatic Brain Injury: Results from the TRACK-TBI Study. Journal of neurotrauma, 38 7, 918-927
Brett, Benjamin L; Kramer, Mark D; Whyte, John; McCrea, Michael A; Stein, Murray B; Giacino, Joseph T; Sherer, Mark; Markowitz, Amy J; Manley, Geoffrey T; Nelson, Lindsay D ; Adeoye, Opeolu; Badjatia, Neeraj; Boase, Kim; Barber, Jason; Bodien, Yelena; Bullock, M Ross; Chesnut, Randall; Corrigan, John D; Crawford, Karen; Diaz-Arrastia, Ramon; Dikmen, Sureyya; Duhaime, Ann-Christine; Ellenbogen, Richard; Feeser, V Ramana; Ferguson, Adam R; Foreman, Brandon; Gardner, Raquel; Gaudette, Etienne; Gonzalez, Luis; Gopinath, Shankar; Gullapalli, Rao; Hemphill, J Claude; Hotz, Gillian; Jain, Sonia; Keene, C Dirk; Korley, Frederick K; Kramer, Joel; Kreitzer, Natalie; Levin, Harvey; Lindsell, Chris; Machamer, Joan; Madden, Christopher; Martin, Alastair; McAllister, Thomas; Merchant, Randall; Mukherjee, Pratik; Ngwenya, Laura B; Noel, Florence; Okonkwo, David; Palacios, Eva; Puccio, Ava; Rabinowitz, Miri; Robertson, Claudia; Rosand, Jonathan; Sander, Angelle; Satris, Gabriella; Schnyer, David; Seabury, Seth; Taylor, Sabrina; Temkin, Nancy; Toga, Arthur; Valadka, Alex; Vassar, Mary; Wang, Kevin; Yue, John K; Yuh, Esther; Zafonte, Ross 2021. Latent Profile Analysis of Neuropsychiatric Symptoms and Cognitive Function of Adults 2 Weeks After Traumatic Brain Injury: Findings From the TRACK-TBI Study. JAMA network open, 4 3, e213467
Stein, Murray B; Yuh, Esther; Jain, Sonia; Okonkwo, David O; Mac Donald, Christine L; Levin, Harvey; Giacino, Joseph T; Dikmen, Sureyya; Vassar, Mary J; Diaz-Arrastia, Ramon; Robertson, Claudia S; Nelson, Lindsay D; McCrea, Michael; Sun, Xiaoying; Temkin, Nancy; Taylor, Sabrina R; Markowitz, Amy J; Manley, Geoffrey T; Mukherjee, Pratik 2021. Smaller Regional Brain Volumes Predict Posttraumatic Stress Disorder at 3 Months After Mild Traumatic Brain Injury. Biological psychiatry. Cognitive neuroscience and neuroimaging, 6 3, 352-359
Agtarap, Stephanie D; Campbell-Sills, Laura; Jain, Sonia; Sun, Xiaoying; Dikmen, Sureyya; Levin, Harvey; McCrea, Michael A; Mukherjee, Pratik; Nelson, Lindsay D; Temkin, Nancy; Yuh, Esther L; Giacino, Joseph T; Manley, Geoffrey T; Stein, Murray B 2021. Satisfaction with Life after Mild Traumatic Brain Injury: A TRACK-TBI Study. Journal of neurotrauma, 38 5, 546-554
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